Nonsteroidal antiinflammatory drugs and aspirin 202 1. This chapter is a revision of the chapter on peptic ulcer disease in the 8th edition written by rosemary r. This video gives an overview of the pharmacological management of peptic ulcer disease. Prevalence of peptic ulcer disease in patients receiving nsaids therapy ranges between 10 and 30%, what is 10 to 30fold increase over that found in the general population. Department of pharmacology and biochemistry, faculty of dental. Peptic ulcer disease remains a relatively common disorder despite its declining incidence.
General and inexpensive measures like introducing healthy lifestyle, stopping smoking and taking antacids should be promoted. The mortality rate for peptic ulcer disease is approximately one death per 10,000 cases. The occurrence of peptic ulcer disease is similar in men and women. These complexes serve as protective barriers at the ulcer surface, preventing further damage from acid, pepsin, and bile. Over the last several decades, the development of potent antisecretory agents h2 blockers and proton pump inhibitors and the recognition that treatment for helicobacter pylori infection can eliminate most ulcer recurrences have essentially eliminated the. Sep 24, 2017 peptic ulcer disease may occur in both genders and in all ages. Gastrointestinal pharmacology antacids peptic ulcer therapy antiemetics laxatives antidiarrheal drugs gastrointestinal pharmacology acid production.
If nsaids are causing your peptic ulcer and you don. Download as ppt, pdf, txt or read online from scribd. In pharmacology of histamine receptors, cr ganellin, me parsons eds. This revolution, based on advances in cellular biology, pharmacology, and health care delivery, has changed forever the treatment of. Drugs used in acidpeptic diseases clinical uses of ppis 1. Drug therapy in peptic ulcer disease the treatment of peptic ulcer disease has undergone a revolution in the past decade. Pdf peptic ulcer disease pud is the erosion of stomach or. Although pud is most commonly caused by helicobacter pylori infection or use of nonsteroidal anti. Drug treatment of peptic ulcer disease open access ebooks. Start studying pharmacology drugs for peptic ulcer disease. Diagnosis and treatment of peptic ulcer disease and h. P h r m a c o l o g y note 3 treatment of peptic ulcer. Peptic ulcer disease pud is a disease of the gastrointestinal gi tract characterized by a break in the mucosal lining of the stomach or duodenum secondary to pepsin and gastric acid secretion, this damage is greater than 5 mm in size and with a depth reaching the submucosal layer.
Gastroesophageal reflux disease gerd most effective agents once or twice daily. Pharmacology of peptic ulcer disease contributors s. Feb 01, 2016 this video gives an overview of the pharmacological management of peptic ulcer disease. The possibilitiy of malignant disease should be considered in all patients over the age of 40 years who. Drugs used in the treatment of peptic ulcer disease may interact with the renal system in a variety of ways. The subsequent association of h pylori with gastritis and peptic ulcer formation and the use of antibiotic regimens in conjunction. Ulcers located near the esophagogastric junction require subtotal gastrectomy with a rouxeny esophagogastrojejunostomy csendes procedure.
Pharmacology peptic ulcer disease dyspepsia gord inflammatory bowel disease irritable bowel syndrome diarrhoea constipation pancreatitis dyspepsia peptic ulcer disease dyspepsia. New groups of compounds with different pharmacokinetics and mechanisms of action are currently being investigated, and it is possible that they will represent an alternative to, or a substitute for, the present widely used anti ulcer drugs. Approximately 11%14% of men and 8%11% of women will develop peptic ulcer disease in their lifetime. Mechanism of action, pharmacology, and side effects view in chinese approach to refractory peptic ulcer disease view in chinese association between helicobacter pylori infection and duodenal ulcer view in chinese cox2 inhibitors and gastroduodenal toxicity. A peptic ulcer is a sore in the lining of the stomach, where it is called a gastric ulcer, or the first part of the small intestine, called a duodenal ulcer. Gastrointestinal pharmacology university of california. Antibiotics antisecretory agents mucosal protectants antisecretory agents that enhance mucosal defenses antacids. A bismuth monotherapy b therapy using bismuth compounds, metronidazole flagyl, and amoxicillin amoxil polymox in combination triple therapy. Professor slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Physiology of gastric acid secretion gastric acid secretion is a complex, continuous process in which multiple central and peripheral factors contribute to a common endpoint. Drugs in peptic ulcer disease handout faculty of medicine. Gi pharmacology metoclopramide domperidone 2 pylori.
Ppt gastrointestinal pharmacology powerpoint presentation. Peptic ulcer disease occurs with the greatest frequency in people between 40 and 60 years of age. I overview on gastrointestinal pharmacology stefano evangelista encyclopedia of life support systems eolss prize in medicine for sir james black. Learn vocabulary, terms, and more with flashcards, games, and other study tools.
The association between peptic ulcer diseases and mental hea. Peptic ulcer disease nursing care and management nurseslabs. Gastric acid physiology secretion, ulcers, acid reflux. Protocol for diagnosis and treatment of peptic ulcer in adults. Pharmacological treatment options peptic ulcer disaese a disease characterized by ulcers in gut mucosa exposed to gastric secretions. Schematic presentation of main pathophysiological mechanisms involved in the.
Gastric ulcers, in the stomach, and duodenal ulcers, in the upper portion of the small intestine, occur most often. In duodenal ulcer, an ulcer is present in the duodenum or the. Muocosal protective agents drugs pharmacokinetic action uses side effect sucralfate. Pharmacology peptic ulcer diseasedyspepsia gord inflammatory bowel disease irritable bowel syndrome diarrhoea constipation pancreatitis dyspepsia peptic ulcer disease dyspepsia. Peptic ulcer disease pud is defined as ulcerations and erosions that occur in the stomach and duodenum. Mucosal injury due to helicobacter pylori infection, nsaid use, zollingerellison syndrome multiple peptic ulcerations in stomach, duodenum and jejunum due to excess gastrin secretion by a tumor, ischemia, bile pancreatic juice reflux alcohol, smoking, copd and corticosteroids use may exacerbate peptic ulcer disease and impair healing. Since many agents are eliminated by renal excretion, clearance of these agents may be. There are several types of medicines used to treat a peptic ulcer. Pancreatic enzymes 11 imbalance factors that protect against acidity factors that increase acid secretion. Pharmacology chapter 62 pharmacotherapy of peptic ulcer.
In the 1980s, the number of elective operations for peptic ulcer disease dropped more than 70%, and emergent operations accounted for more than 80%. For example protonpump inhibitors are used in the treatment of peptic ulcer disease, nsaidassociated ulcers, gerd and the eradication of h. Nsai, aspirin, cortisone and cytotoxic drugs cigarette smoking. Peptic ulcer disease pud pathophysiology is the property of its rightful owner. It is the presence of ulcerations in gastrointestinal tract, which is characterized by being acidic, extremely painful. Peptic ulcer pu is defect in the gastrointestinal mucosa usually located in the stomach. Elective peptic ulcer surgery has been virtually abandoned. Your doctor will decide the best treatment based on the cause of your peptic ulcer. Peptic ulcer disease differs from gastritis and erosions in those ulcers. Peptic ulcer disease usually occurs in the stomach and proximal duodenum.
Interestingly, those at the highest risk of contracting peptic ulcer disease are those. Gi pharmacology diffuse mucosal inflammation limited to the colon. New groups of compounds with different pharmacokinetics and mechanisms of action are currently being investigated, and it is possible that they will represent an alternative to, or a substitute for, the present widely used antiulcer drugs. Peptic ulcer ulcer disease is caused by peptic ulceration that involves the stomach, duodenum, and lower oesophagus. For an overview of peptic ulcer disease, please take a look at the fo. Peptic ulcer disease symptoms, treatment, pathophysiology. Patients with peptic ulcer disease pud should reduce psychological stress, cigarette smoking, and nonsteroidal antiinflammatory drug nsaid use and avoid foods and beverages that exacerbate ulcer symptoms. Pdf on may 30, 2019, monjur ahmed and others published peptic ulcer disease find, read and cite all the. Stomach ulcer peptic acid disease medication pharmacology lecturio duration. Pharmacology of the treatment of peptic ulcer disease. This protocol may be used by general practitioners, family doctors, and nurses. Ppis work through the irreversible inhibition of the proton pump a pump found on gastric parietal cells. A powerpoint presentation on peptic ulcer drugs suitable for ug mbbs.
Protonpump inhibitors pharmacology all the facts in one place. It interferes with the integrity of gastrointestinal mucosal layer within esophagus, stomach and proximal part of small intestine, called duodenum. Peptic ulcer disease is an erosion or lesion in the lining of digestive tract. Protocol for diagnosis and treatment of peptic ulcer in. Pharmacodynamics basic notes pdf ppt atropine furosimide heparin basti vamana pharmacodynamics example, pharmacodynamics basics, pharmacodynamics pdf, pharmacodynamics ppt, pharmacodynamics vs pharmacokinetics, pharmacodynamics definition. Ppt peptic ulcer disease pud pathophysiology powerpoint. One out of 175 users of nsaids in the usa will be hospitalized each year for nsaidsinduced gastrointestinal damage. Pharmacology drugs for peptic ulcer disease quizlet. Ulcers are caused by an infection of a bacterium known as helicobacter pylori or h. Peptic ulcer disease pud is one of the commonest diseases seen throughout. Quizlet flashcards, activities and games help you improve your grades. Americans will have an ulcer in their life most common cause 85%.
Treatment of peptic ulcer disease involves stopping bleeding by. At presentation, the patients hemodynamic status pulse, blood pressure. The predominant causes in the united states are infection with helicobacter pylori and use of nonsteroidal anti. This revolution, based on advances in cellular biology, pharmacology, and health care delivery, has changed forever the treatment of this major disease. The treatment of peptic ulcer disease has undergone a revolution in the past.
This teachable moment examines the case of a man in his 70s who presented to the emergency department 2 weeks after discontinuation of proton pump inhibitors ppis to caution against abrupt ppi discontinuation in patients with multiple risk factors for peptic ulcer disease. It also attaches to proteins on the surface of ulcers, such as albumin and fibrinogen, to form stable insoluble complexes. A bleeding duodenal ulcer, viewed during endoscopy. With the success of medical therapy, surgery has a very limited role in the management of peptic ulcer disease. Start studying pharmacology chapter 62 pharmacotherapy of peptic ulcer disease. Peptic ulcer disease in both types of peptic ulceration, gastric and duodenal, there is an imbalance between secretion and neutralization of secreted acid. Antisecretory therapy is the keystone of therapy in patients with pud.
Nsaid associated ulcer once daily therapy eradication 2 antibiotics and ppi 714 day therapy lansoprazole 2x 20mg 19 2. If you continue browsing the site, you agree to the use of cookies on this website. Fortunately, integrative interventions including deglycyrrhizinated licorice dgl, zinccarnosine, and lactobacillus reuteri have powerful ulcerhealing. A free powerpoint ppt presentation displayed as a flash slide show on id. This study aimed to investigate the association between the prevalence of peptic ulcer disease pud and mental health problems, such as severe stress, depressive mood, and suicidal ideation the populationbased crosssectional study was comprised of 14,266 subjects participating in the fourth annual korea national health and nutrition examination survey from 2007 to 2009. Many drugs are similar to or have similar chemical groups to the naturally occurring chemical and have the ability to bind onto a receptor where one of two things can happen either the receptor will respond or it will be blocked. The stomach is an outpocket of the gastrointestinal tract in which ingested food undergoes mechanical and chemical changes that promote absorption in the small and large intestine.
Gi pharmacology acidpeptic diseases antiemetics inflammatory bowel disease therapies pancreatic enzyme supplements bile acid therapy chronic viral hepatitis acid peptic disease dyspepsia. Eradication oi helicobacter pylori and peptic ulcer disease i. Pharmacodynamics basic notes pdf ppt atropine furosimide. Drugs used in acid peptic diseases clinical uses of ppis 1. Peptic ulcer is a lesion of the mucosal lining of the upper gastrointestinal tract characterized by an imbalance between aggressive and protective factors of the mucosa, having h. Gastrointestinal pharmacology peptic ulcer disease 25 mill. Prevention of recurrence of nonsteroidal antiinflammatory drug nsaid associated gastric ulcers in patients who continue nsaid use. Peptic ulcer drugs and pharmcotherapy drdhriti slideshare. Gastric acid physiology secretion, ulcers, acid reflux and treatment.
It is relatively uncommon in women of childbearing age, but it has been observed in children and even in infants. Because of the disruption of the normal mucosal defense, pud can provoke many symptoms and signs such as dyspepsia, abdominal pain, and hemorrhage. Introduction peptic ulcer disease represents a serious medical problem. Helicobacter pylori hp in patients with suspected peptic ulcer disease pud. Gitu, md, florida state university college of medicine family medicine. The association between peptic ulcer diseases and mental. Pharmacokinetics absorption is not interfered by food can cross.
Eradication is recommended for all helicobacter pyloripositive patients, especially those patients with an active ulcer, a documented history of a prior ulcer, or a history of ulcer. If so, share your ppt presentation slides online with powershow. Peptic ulcer disease pharmacological treatment pharmaceutical. Peptic ulcer disease2 free download as powerpoint presentation. Pharmacodynamics basic notes pdf ppt atropine furosimide heparin basti vamana pharmacodynamics example, pharmacodynamics basics, pharmacodynamics pdf, pharmacodynamics ppt, pharmacodynamics vs pharmacokinetics, pharmacodynamics definition nursing, pharmacodynamics slideshare. Peptic ulcer disease was once the most common indication for gastric surgery but now only infrequently requires operation. A peptic ulcer disease or pud is an ulcer defined as mucosal erosions equal to or greater than 0. Indeed, with the introduction of ppis, the healing and cure rates have improved dramatically. Peptic ulcer disease pud is one of the most common diseases affecting the gastroinestinal gi tract. Antrectomy including the ulcer with a billroth i anastomosis is the treatment of choice for an antral ulcer. Approximately 500,000 new cases are reported each year, with 5 million people affected in the united states alone. In duodenal ulcers there is an oversecretion of acid whilst in gastric ulcers there is an impairment of mucosal protection rapid urease tests are considered the endoscopic diagnostic.
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